Real-world evidence for the effectiveness and breakthrough of BNT162b2 mRNA COVID-19 vaccine at a medical center in Japan일본 의료 센터에서 BNT162b2 mRNA COVID-19 백신의 효과 및 돌파구에 대한 실제 증거Article Published on 2022-12-312022-09-11 Journal: Human vaccines & immunotherapeutics [Category] COVID19(2023년), SARS, 변종, [키워드] Asia Asian BNT162b2 BNT162b2 vaccine breakthrough COVID-19 vaccine delta variant demonstrated Effectiveness Effectiveness. Evidence evidence of hospital hygiene Infection infection control Japan measure mRNA of BNT162b2 Population populations Public hygiene Regulation required retrospective cohort study SARS-CoV-2 Spread Tokyo vaccination Vaccine variant while [DOI] 10.1080/21645515.2021.1984124 PMC 바로가기 [Article Type] Article
Effects of Human Nucleolus Upon Guest Viral-Life, Focusing in COVID-19 Infection: A Mini- ReviewReview Article Published on 2022-12-152022-10-29 Journal: Iranian Journal of Pathology [Category] COVID-19, [키워드] accumulating biogenesis Cell cell stress concerning coronavirus disease Coronavirus infections COVID-19 DDR disrupt DNA damage Effect endotheliopathy eukaryotic cells Evidence Focusing function gene silencing Human human diseases MINI nucleoli Nucleolopathy Nucleolus nucleus organism Organisms pathogenic precursor Protein provided Regulation Replication review subcellular tRNA viral infection viral infections virus [DOI] 10.30699/IJP.2021.540305.2744 PMC 바로가기 [Article Type] Review Article
Population-weighted exposure to green spaces ties to lower COVID-19 mortality rates: A nationwide dose-response study in the USAResearch article Published on 2022-12-012022-10-05 Journal: The Science of the total environment [Category] 유전자 메커니즘, 진단, [키워드] adjusted adopted association buffer caused chronic disease confidence interval Contact with nature COVID-19 mortality COVID-19 pandemic Critical decrease distribution ecological Effect effect size environmental factors forest greater Health increase in investigated knowledge Landscape planning and design linear mechanism mitigate mixed-effects model Mortality mortality rate mortality rates Nearby nature Optimal dose of nature promote PROTECT Regulation Research risk of COVID-19 SARS-CoV-2 Sociodemographic USA with COVID-19 [DOI] 10.1016/j.scitotenv.2022.158333 [Article Type] Research article
The impact of COVID-19 on Italian adolescents’ sleep and its association with psychological factorsArticle Published on 2022-12-012022-11-16 Journal: Journal of Sleep Research [Category] COVID19(2023년), SARS, 치료기술, [키워드] adolescents association behavioural collected coronavirus disease correlated COVID-19 COVID-19 pandemic develop different time point dysregulation emotional Factor General population Health hygiene independent Insomnia Interaction Intervention Italian large sample later phase measure outbreak pandemic Prevalence problem promote Psychological Psychological distress psychological health Psychological problems Psychology recent recruited Regulation Result risk factor shown Sleep. Symptom Symptoms time variable variables [DOI] 10.1111/jsr.13689 PMC 바로가기
Epigenetic perspectives of COVID-19: Virus infection to disease progression and therapeutic controlResearch article Published on 2022-12-012022-10-05 Journal: Biochimica et biophysica acta. Molecular basis of [Category] COVID19(2023년), SARS, 변종, 신약개발, 유전자 메커니즘, 치료제, [키워드] ACE2 analysed antagonistic autophagy caused Cell cellular metabolism cellular processe Course COVID-19 death Disease progression enzyme Epigenetic epigenetics example expression profile function genes encoding Genome Host host cell IL-6 Infection investigated Laboratory Lipid mechanism membrane metabolic activity metabolic pathway methionine pathogen invasion patients Perspective progression rDNA Regulation replication mechanism ribosome S-adenosylmethionine SARS-CoV-2 sera social isolation the disease the patient therapeutic therapy tissue viral loads virus virus particle virus replication [DOI] 10.1016/j.bbadis.2022.166527 [Article Type] Research article
Wastewater surveillance allows early detection of SARS-CoV-2 omicron in North Rhine-Westphalia, GermanyArticle Published on 2022-11-102022-11-15 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] Analysis approach close monitoring collected COVID-19 COVID-19 surveillance demonstrated detection Detection workflow dominant variant Epidemiology evaluate fraction Germany identify Initially K417N Laboratory Local MONITOR mutant Mutation N501Y NGS North omicron Omicron, B.1.1.529 PCR primer public health purified Regulation required resulting RT-qPCR SARS-CoV-2 SARS-CoV-2 epidemiology SARS-CoV-2 monitoring SARS-CoV-2 RNA SARS-CoV-2 variant Sequencing state subsequent Support Surveillance Treatment variant variant of concern was performed wastewater Wastewater-based epidemiology (WBE). [DOI] 10.1016/j.scitotenv.2022.157375 PMC 바로가기
Hydrothermal deconstruction of single-use personal protective equipment during the COVID-19 pandemicArticle Published on 2022-11-012022-11-15 Journal: Waste management (New York, N.Y.) [Category] SARS, 치료기술, [키워드] acetic adopted ammonia carbon dioxide Concentration Contamination COVID-19 COVID-19 pandemic Fatty acid Hydrothermal deconstruction increase in initial Isolation lowest Masks oxygen Personal protective equipment PPE produced Protective Regulation selected surgical temperature the SARS-CoV-2 virus Transmission TSS was reduced waste waste management Wet Wet oxidation. [DOI] 10.1016/j.wasman.2022.09.006 PMC 바로가기
Transcriptional regulation and small compound targeting of ACE2 in lung epithelial cellsArticle Published on 2022-11-012022-11-15 Journal: Acta pharmacologica Sinica [Category] COVID19(2023년), SARS, 진단, [키워드] 16HBE 16HBE cell 16HBE cells 6-O-angeloylplenolin ACE2 ACE2 expression addition administration Cell Centipeda Centipeda minima chemokine Chinese Compound conducted COVID-19 CX3CL1 CXCL13 dataset demonstrated downregulated entry of SARS-CoV-2 enzyme evaluated expression gene encoding HLF IL-6 inhibited inhibitor Interaction lung epithelial cell Lung epithelial cells lung tissue lung tissues mice modulate parental pathogen phosphorylated positively correlated promoter PROTECT Protein pseudovirus receptor reduced regulate Regulation S protein SARS-CoV-2 SARS-COV-2 infection screened STAT3 STAT3. stimulated suppressed target cells tested TFS Transcription transcription factor transfected with [DOI] 10.1038/s41401-022-00906-6 PMC 바로가기
Interaction of HDAC2 with SARS-CoV-2 NSP5 and IRF3 Is Not Required for NSP5-Mediated Inhibition of Type I Interferon Signaling PathwayArticle Published on 2022-10-262022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 치료제, [키워드] abrogate activated addition bind binding biological significance cellular processe complex disrupt DNA Epigenetic Evidence expression favor Gene Expression HDAC2 Host host antiviral response IFN response IFN signaling pathway IFN-stimulated genes IFNβ IL-1β IL-6 immune response gene inhibit inhibition inhibitory interact Interaction interferons involved IRF3 nsp5 over Pathogenesis pathway promote promoter promoters protease Protease activity protein interaction protein-protein interactions reduce Regulation Replication repress required RNA SARS-CoV-2 SARS-CoV-2 protein Signaling signaling pathway significantly subset Type Type I IFN type I IFN signaling. type I interferon viral infection viral infections Viral protein virus [DOI] 10.1128/spectrum.02322-22 PMC 바로가기
Reconstructed Genome-Scale Metabolic Model Characterizes Adaptive Metabolic Flux Changes in Peripheral Blood Mononuclear Cells in Severe COVID-19 PatientsArticle Published on 2022-10-172022-11-15 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제, [키워드] acute respiratory syndrome adaptive aerobic Analysis anti-inflammatory effect antiviral drugs biogenesis caused change changes in Coronavirus disease 2019 Coronavirus-2 COVID-19 differentially expressed enzyme FASN fatty flux Glycolysis Health Immune cell Inflammation Inflammatory lipids mechanism metabolic metabolic model metabolism metabolism-directed therapy. metabolites Model mononuclear cell nucleotide oxidative phosphorylation pathogenic PBMC PBMCs peripheral Peripheral blood potential therapeutic targets provide reaction reconstructed Regulation responsible retinol SARS-CoV-2 severe COVID-19 patients SLC2A3 therapy Transcriptome Treatment Vitamin [DOI] 10.3390/ijms232012400 PMC 바로가기